A compound found in soil microbes could eventually contribute to a powerful new treatment for B-cell lymphomas, researchers have announced.
The Herbert Wertheim UF Scripps Institute in Florida, USA, has a historic collection of soil microbes and that was where Institute scientists found a compound called tiancimycin. The collection has 125,000 microbes that were collected in the last century in the wake of the discovery of penicillin.
The researchers tested antibody-drug conjugates (ADCs) containing modified versions of tiancimycin on B-cell lymphoma cell lines and cells donated by patients. They say these ADCs showed a “striking ability” to kill aggressive lymphoma cells while ignoring healthy cells.
The findings have been reported in t...
17 hours ago
