Researchers have revealed a previously unappreciated role for a group of proteins called KRAB zinc finger proteins (KZFPs), finding that they can help lymphoma cells avoid immune system detection.
KZFPs are transcription factor proteins which control which genes are switched on or off. Some KZFPs interact with transposable elements (TEs), which make up more than half of the human genome. TEs can cause genomic instability if left unchecked, so KZFPs play a crucial role in repressing TEs and ensuring genomic stability, by packaging TEs into ‘heterochromatin’.
However, some KZFPs are also known to promote disease progression in some cancers. The Swiss team set out to investigate whether the same was the case in diffuse large B cell lymphom...
7 hours ago