Myeloma cells diversify dramatically when they escape from the bone marrow, according to a major new study of the disease.
More than 30 researchers in Berlin and Heidelburg, Germany, and London, UK, worked together on the project to examine events within focal lesions, when the disease breaks out of the bone, using innovative single cell and spatial omics technologies.
Their findings point immediately to potential changes to the way the disease is monitored, they say.
The researchers suspect that the diversification of the cells enables them to adapt outside the bone marrow and to spread to other parts of the body.
The researchers also examined how the immune system reacted to the break-out of the cells. This showed significant changes t...
2 days ago
