Belgian researchers have unveiled the first ‘atlas’ of the multiple myeloma immune microenvironment in a mouse model.
The research team, based in Brussels, believe their work can help guide developers of new immunotherapies.
Their atlas is based on single cell RNA sequencing across stages of the disease, in an immunocompetent mouse model, and corroborated with similar data from human patient samples.
The work led to some general discoveries about the immune microenvironment of the disease, finding an increase in T cells, especially in an ‘exhausted’ state. Early in the disease, neutrophils appeared “innocuous” but acquired cancer-triggering characteristics during the development of the disease. The researchers also found that conventiona...
2 days ago
