A Spanish team announced the successful development of a new mouse model of the immune system.
The researchers at the Josep Carreras Leukaemia Research Institute have bred new humanised mice, whose immune systems have been generated using mononuclear cells from cord blood.
The use of ‘humanised’ mice has aided the study of the interaction between various cancers and the immune system, and boosted development of cancer immunotherapies.
However, previous methods for generating humanised mice were either too slow or often led to severe graft-versus-host disease. The resulting humanised mice also had an imbalance in the representation of myeloid versus lymphoid immune cells.
Reporting in the Journal for Immunotherapy of Cancer, the scientist say their new method, using cord-blood cells and a new type of immunodeficient mouse, has limited graft-versus-host-disease, and has sustained a balanced representation of all immune cell types.
Source:
Panisello C, Aschero R, Martinez-Moreno A, Roca Ho H, Falgas A, González-Navarro EA, Carabelli J, Pradenas E, Lázaro-Díez M, Prado JG, Blanco J, Carrillo J, Juan M, Carcaboso ÁM, Bueno C, Menendez P. (2024) “NSGS mice humanized with cord blood mononuclear cells show sustained and functional myeloid-lymphoid representation with limited graft-versus-host disease.” Journal for Immunotherapy of Cancer, 7 October 2024, doi: 10.1136/jitc-2024-009198.
Link: https://jitc.bmj.com/content/12/10/e009198.info
Disclaimer: The news stories shared on this site are used as a way to inform our members and followers of updates and relevant information happening in Haematology. The BSH does not endorse the content of news items from external sources, and is not in a position to verify the findings, accuracy or the source of any studies mentioned. Any medical or drugs information is provided as an information resource only, and is not to be relied on for any diagnostic or treatment purposes.
News service provided by Englemed News.